3 4 5 6 7 They have been shown to carry a substantial

Briefly, samples containing more than 0.5 g/ml D dimer produce a blue colour in the presence of nitroblue tetrazolium, the intensity of which reflects the concentration of D dimer. D dimer results were scored as normal (no colour development), abnormal, or inadequate for interpretation. Assuming an expected prevalence of 30% for deep vein thrombosis we calculated that about 900 patients would be necessary to yield sufficiently narrow confidence intervals around the expected number of venous thromboembolic complications..

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pandora rings IntroductionAntithrombotic treatments are widely used in post myocardial infarction patients to reduce thromboembolic risk, but at the cost of increased risk of bleeding.1 2 Gastrointestinal haemorrhage is the most common serious bleeding complication associated with antithrombotic treatment.1 Non steroidal anti inflammatory drugs (NSAIDs) are effective and widely used analgesics. Much attention has been given to their gastrointestinal safety.3 4 5 6 7 They have been shown to carry a substantial independent risk of bleeding in cardiovascular patients when co prescribed with antithrombotics, even with short term use (8 9 10 Randomised controlled trials have reported that proton pump inhibitors (PPIs) reduce rates of recurrent gastrointestinal bleeding in patients receiving antithrombotics.11 12 Although NSAIDs are discouraged in post myocardial infarction patients, pain is a common condition and, in practice, they are frequently prescribed.13 14 American specialist cardiology and gastroenterology guidelines recommend that PPIs should be used with both antithrombotic and NSAID treatments in patients judged to be at high risk of gastrointestinal bleeding.15 In the United Kingdom, the National Institute for Health and Care Excellence (NICE) recommends routine PPI co prescription with NSAIDs for everyone aged 45 years and older with osteoarthritis, rheumatoid arthritis, or chronic low back pain,16 as well as for people taking antithrombotics who are at high risk of gastrointestinal adverse effects including bleeding.17 However, the potential benefit of PPI therapy used with antithrombotic/NSAID combinations in post myocardial infarction patients irrespective of gastrointestinal risk is unknown. We therefore investigated the effect of PPIs on the risk of bleeding in Danish post myocardial infarction patients taking antithrombotics who were also treated with NSAIDs pandora rings.